An analysis has been carried out to examine the water based nanofluid flow with silver nanoparticles. Flow due to a rotating disk with variable thickness is considered. Heat and mass transfer subject to volume fraction of nanoparticles and homogeneous-heterogeneous reactions are examined. Homotopy concept is utilized for the development of solutions. Special emphasis is given to the non-dimensional velocity, temperature, concentration, skin friction coefficient and Nusselt numbers. It is observed that with an increase in disk thickness the radial, axial and azimuthal velocities are enhanced. Here surface shear stress rates decays for larger thickness coefficient of disk while increases for volume fraction of silver based nanoparticles. Magnitude of heat transfer rate decreases for Reynold number. (C) 2017 Elsevier Ltd. All rights reserved.