Those comments from Acree on "Effect of beta-alanine and the solvent composition on the solubility of solvate of calcium D-pantothenate containing four molecules of methanol and one molecule of water (D-PC center dot 4MeOH center dot 1H(2)O)" are very valuable and helpful for improving the quality of our paper. Here according to the comments, we make a deep analysis and discussion of our article again. Firstly, we need to make a restatement that So and S actually represent the solubility with no impurity in the solution and the solubility in the solution containing impurity in our article, respectively. Secondly, the experimental solubility was reanalysed by the new Cohen equation suggested by Acree Jr, and the results show that the original Cohen equation could give the better agreement. Finally, the modified Solubility-Polarity equation was adopted to correlate the solubility in terms of the relative dielectric constant. (C) 2017 Published by Elsevier Ltd.