The Seveso accident triggered a virtuous process towards the development of methods, models and tools for safety and risk assessment and management. Among the more relevant results of such process was the stemming of methods and tools addressing the transportation of hazardous substances in the framework of a holistic approach to the control of major accident hazards related to dangerous substances. The present study aims at the analysis of reference procedures and tools available for the analysis of the risk in the transportation of dangerous substances in the light of the Viareggio accident. The Viareggio accident represents a paradigmatic event involving the transportation of dangerous substances. The accident, that took place in Italy in 2009, was analyzed in the perspective of current approaches to the analysis of risk in the transportation of hazardous materials. The results pointed out that the Viareggio scenario, although of particular severity, is comprised within those accounted in quantitative risk analysis. (C) 2016 Elsevier Ltd. All rights reserved.