Relative rate experiments were used to measure the rate constant and temperature dependence of the reaction of OH radicals with 2-fluoropropane (HFC-281ea), using ethane, propane, and ethyl chloride as reference standards. Measurements were made using both infrared spectroscopy and gas chromatography (GC). Results from the two measurement techniques were in good agreement, with the GC data being more precise. The rate at 298 K for HFC-281ea, based on the GC experiments, was found to be 5.7 x 10(-13) cm(3)/(molecule s), with Arrhenius A factor = 3.06 x 10(-12) cm(3)/(molecule a) and E/R = 503 K. A previously described estimation technique, along with an improved method to estimate the Arrhenius parameters, is used to predict a rate constant and temperature dependence for 2-fluoropropane, which is in good agreement with the experimental value. A prediction is also made for 1-fluoropropane, for which there are no data.