Recent research has demonstrated promising results showing the possibility of separating arsenic-copper sulphides from other copper minerals by controlling the potential of the flotation pulp. Most of these studies were conducted on single mineral systems, and the selective removal of arsenic-copper minerals in real ore systems is not well understood, particularly, the effects of mineralogical properties such as liberation and mineralogical association. In this study, two distinct ore samples, termed low arsenic sample (LAS) and high arsenic sample (HAS) were selected from the Tampakan copper-gold deposit in the Philippines, providing a range of arsenic levels. The selective separation of enargite from other copper sulphide minerals in a rougher flotation system under controlled pulp potential was investigated for both samples.