Hecogenin is a product with high potential in the pharmaceutical industry, which may be extracted from the liquid waste of sisal (Furcraea spp.). A powder product from the liquid extract was obtained using spray drying, and the process was optimized according to the operating conditions of the dryer and quality properties of the final product. The results indicate that the best conditions are achieved at the inlet and outlet air-drying temperatures of 160 degrees C and 82.6 degrees C, respectively, and an atomizer disc speed of 26,800 rpm. For these conditions, we obtained a powder yield of 62.2%, stickiness of 14%, a moisture content of 3.98% w.b, a solubility of 98.86%, a water activity of 026 and a hecogenin content 2924 mg/kg. Additionally, the effect of the moisture content on the glass transition temperature (T-g) of the powder was evaluated. (C) 2017 Elsevier B.V. All rights reserved.