화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Journal of Industrial and Engineering Chemistry, Vol.56, 99-107, December, 2017
DOI10.1016/j.jiec.2017.07.002  Export Citation
Solubility and thermodynamic function of apremilast in different (Transcutol + water) cosolvent mixtures: Measurement, correlation and molecular interactions
Faiyaz Shakeel1, 2, †, Nazrul Haq3, Fars K. Alanazi3, and Ibrahim A. Alsarra3
  • 1Kayyali Chair for Pharmaceutical Industry, Department of Pharmaceutics, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451 Saudi Arabia
  • 2Center of Excellence in Biotechnology Research (CEBR), King Saud University, P.O. Box 2460, Riyadh 11451, Saudi Arabia
  • 3Kayyali Chair for Pharmaceutical Industry, Department of Pharmaceutics, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia
E-mail:
The solubility of apremilast (APM) in different “Transcutol® + water” cosolvent mixtures was determined and correlated at “T = 298.2 K-318.2 K” and ‘p = 0.1 MPa’. The experimental solubilities of APM were determined and correlated with “Apelblat, van’t Hoff, Yalkowsky and Jouyban.Acree equations”. The maximum solubilities of APM in mole fraction were obtained in neat Transcutol (2.53 x10 -2 at T = 318.2 K). Based on activity coefficients, strong molecular interactions were obtained between APM and neat Transcutol in comparison with APM and neat water. “Apparent thermodynamic analysis” showed an “endothermic and entropy-driven dissolution” of APM.
Keywords:Apremilast;Activity coefficient;Cosolvent mixture;Solubility;Thermodynamics
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