화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Journal of Industrial and Engineering Chemistry, Vol.56, 258-269, December, 2017
DOI10.1016/j.jiec.2017.07.018  Export Citation
Synthetic polyphenol compounds inhibit b-catenin/Tcf signaling: Structure-activity relationship
Seunghyun Ahn1, 2, Eunsook Ahn1, Jiha Sung1, Dongsoo Koh1, Yoongho Lim2, and Seyeon Park1, †
  • 1Department of Applied Chemistry, Dongduk Women’s University, Seoul 136-714, Republic of Korea
  • 2Division of Bioscience and Biotechnology, BMIC, Konkuk University, Seoul 143-701, Republic of Korea
E-mail:
Activated b-catenin/T-cell factor signaling has been shown to be involved in human carcinogenesis. Here, the inhibitory effects of various synthetic naphthoflavones and napthochalcones on β-catenin/Tcf signaling in β-catenin overexpressing-cells were investigated and compared. The naphthoflavones with a β-angular pattern (5,6-benzoflavone series) resulted in a more potent inhibitory activity than those with an a-angular pattern (7,8-benzoflavone series), indicating that the direction of the naphthyl ring is an important determinant of inhibitory activity. This result is in accordance with the napthochalcone derivatives. Moreover, in silico docking results supported our in vitro biological results.
Keywords:β-catenin/Tcf signaling;Inhibitor;Naphthoflavone;Napthochalcone;In silico docking
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