화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Journal of Industrial and Engineering Chemistry, Vol.57, 424-435, January, 2018
DOI10.1016/j.jiec.2017.08.051  Export Citation
Naturally modified nonionic alginate functionalized upconversion nanoparticles for the highly efficient targeted pH-responsive drug delivery and enhancement of NIR-imaging
Salah M. Tawfik1, 2, Mirkomil Sharipov1, Bui The Huy1, Zayakhuu Gerelkhuu1, Dana Biechele-Speziale3, and Yong-Ill Lee1, †
  • 1Anastro Laboratory, Department of Chemistry, Changwon National University, Changwon 51140, Republic of Korea
  • 2Department of Petrochemicals, Egyptian Petroleum Research Institute, Cairo, Egypt
  • 3Department of Chemistry, Western Kentucky University, Bowling Green, KY, USA
E-mail:
Naturally modified nonionic alginate-based polymers were synthesized to act as functionalizing agents for upconversion nanoparticles (UCNPs). The synthesized polymer-UCNPs hybrid nanoparticles show high stability, excellent biocompatibility and enhanced luminescence intensity for NIR imaging. Additionally, our results show that due to the large cavities of the materials and amphiphilic polymer shell, these nonionic alginate-functionalized UCNPs were able to load the anticancer drug doxorubicin (DOX) with the exceptional efficiency as well as release it in a highly controlled and selective pH-responsive manner via folate receptor-mediated endocytosis. Targeting using this multifunction polymer significantly improved the capability of DOX-loaded UCNPs to inhibit the growth of KB cancer cells than free DOX. These biocompatible nonionic alginate-functionalized UCNPs hold substantial potential as effective anticancer drug-delivery carriers and NIR imaging agents.
Keywords:Non-ionic alginate;Upconversion nanoparticles;pH-responsive;Doxorubicin;NIR imaging
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