Liquid templating is a well-established method for the fabrication of monodisperse microparticles. Nearly all liquid templating methods use totally immiscible liquids for the generation of monodisperse liquid droplets. With this approach, it is difficult to mass produce monodisperse droplets in the submicron range. The approach also suffers from some common difficulties associated with the use of small openings or channels required for the generation of small sized droplets including high back pressures and frequent blockage of the flow channels. Aimed at overcoming these difficulties, this paper presents a new co-flowing method that uses partially miscible liquids for the generation of a monodisperse liquid template. The results show that addition of a co-solvent in the inner phase that makes the liquid systems partially miscible changes the bulk and interfacial properties of the liquids that facilitate the generation of smaller droplets. They also confirm that the co-solvent concentration in the inner phase can be used as an additional tool to manipulate the mean size of the resultant droplets and solid particles. Crown Copyright (C) 2017 The Society of Powder Technology Japan. Published by Elsevier B.V. All rights reserved.