The support structure of an offshore wind turbine (OWT) accounts for up to 25% of the capital cost; therefore, investigations into reliable and efficient foundations are critical for the offshore wind turbine industry. This paper describes an innovative hybrid monopile foundation for OWTs, which is an optimization of the original monopile foundation with broader applications. The behavior of OWTs with the hybrid monopile foundation in service conditions are investigated under lateral cyclic loadings, by considering the effects of wind, waves, and ice. A series of centrifuge tests are conducted in order to analyze these behaviors in detail, and OWT models with the original single-pile as well as wheel-only foundations are tested for comparison. Based on these tests, the accumulated lateral displacement and stiffness during cyclic loadings are presented, and the results indicate that the hybrid foundation exhibits a larger cyclic capacity than the other foundations. The influence of the cycle numbers, cyclic loading characteristics, and soil properties is examined during the tests; furthermore, the effects of these factors on the model deformation responses are illustrated. This study proposes the first analytical method for quantitatively estimating the cyclic lateral displacement of the new hybrid foundation in service conditions, and a degradation coefficient is recommended based on the test results. This method aims to provide a simple approach to predicting responses of OWTs with hybrid monopile foundations in service conditions.