The current study evaluates and compares the stability of anaerobic digestion of Brewery Spent Grains (BSG) with and without addition of nutrients. Based on the composition of the BSG two levels of nutrients addition were defined. Control reactor, without addition of nutrients, showed signs of instability after 3 months of operation and collapsed. On the contrary, supplemented reactors led to a COD removal rate of 60% and a methane production of 280 NL CH4.kg(-1) VSadded. According to these results, it was possible to define an additive solution adapted to BSG degradation.