The capture of CO2 by means of a microalgae culture solution was explored in a continuous bubble-column scrubber under a constant pH environment. Optimum conditions for a pilot-scale study were evaluated. With the Taguchi method, a total of sixteen runs were required. Absorption rate, absorption efficiency, overall mass transfer coefficient, and gas-liquid flow rate ratio were determined by a material balance model and a two-film model under steady-state conditions. From the signal-to-noise ratio, the sequence of parameters could be stated. Uncontrolled experiments were also performed and empirical equations were discussed.