Using a synthetic particle model, viscous fluid flow through packed beds of porous particles is directly simulated at the pore scale (1000 angstrom) using the lattice Boltzmann method to characterize intraparticle and interstitial flow. Synthetic particle models are derived from synthesis conditions, scanning electron and focused ion- beam microscopy. A fully porous particle (FPP) and a superficially porous particle ( SPP), derived from the FPP, both with the same external surface, are studied. Packed beds of random packings and body- centered cubic packings of the SPP and FPP models were generated by a Monte Carlo procedure that employs random translation and rigid- body rotation of the particles. Detailed velocity distributions are presented for the interstitial and intraparticle regions of the packed beds and within the particles. These results confirm that porous particle packed beds are heterogeneous systems which require extensions to classical theory for correctly predicting the resistance to flow. It is shown that SPPs require less pressure than FPPs to maintain the same flow velocity. For the random SPP and FPP packed beds, the particle hull mass flux is approximate to 10% of the interstitial flux and approximate to 3% of the total volumetric flux in the flow direction through the SPP hull. The calculated intraparticle pore velocities confirm that an internal flow, characteristic of "perfusion" chromatography, exists within the porous shell that can enhance biomolecular separations. (C) 2017 Elsevier Ltd. All rights reserved.