The combination of capillaries with different internal diameters was used to accelerate the separation of enantiomers in capillary electrophoresis. Separation of R,S-1,1-binaphthalene-2,2-diyl hydrogen phosphate using isopropyl derivative of cyclofructan 6 was studied as a model system. The best separation conditions included 500mM sodium borate pH 9.5 with 60mM concentration of the chiral selector. Separation lasted approx. 1.5min using the combination of 50 and 100m id capillaries of 9.7cm and 22.9cm, respectively. It allowed approx. 12-fold acceleration in comparison to the traditional long-end separation mainly due to the higher electroosmotic flow generated in the connected capillaries.