The paper presents an energy simulation-based study to investigate the impacts of climate change on energy consumptions of an office building located in five different cities, United States. Annual energy consumption of a medium-size office building was predicted by building energy simulation software EnergyPlus using TMY3 weather data and future climate data. In this study, we have used two sets of further climate data with different climate models including (1) Hadley Centre Coupled Model, version 3 (HadCM3), and (2) NCAR Community Earth System Model version 1 (CESM1) with the Community Atmosphere Model version 5 (CAMS). A morphing method was applied to downscale the monthly weather forecast to hourly forecast for use in building energy simulation for the two General Circulation Models (GCMs): HadCM3 and CESMI. Using the generated future weather files, HVAC operation related mitigation measures including adjustment of thermostat setpoints, reduced HVAC operation hours, reduced VAV box minimum flow setting, and mixed-mode ventilation were simulated to compare with ASHRAE Standard 90.1 baseline simulated using TMY3 weather data. Simulation results on predicted whole building, heating and cooling energy consumptions were examined. The paper highlighted the importance of efficiently operating mechanical systems in buildings to ensure a more sustainable future. (C) 2017 Elsevier B.V. All rights reserved.