The purpose of current work is to experimentally investigate the combustion and emission of 2-butanol/diesel RCCI mode on a light-duty diesel engine under various engine loads. The results revealed the 2-butanol/diesel RCCI combustion mode has an accepted COV (coefficient of variation) in IMEP (indicated mean effective pressure), which was below 2% under various engine loads. Compared with CCM (conventional combustion mode), the RCCI combustion led to the increase of peak combustion pressure, maximum RoHR (rate of heat release), premixed combustion proportion and RoPR (rate of pressure rise), but also caused the decrease of RoHR duration as well as combustion temperature. The BTE (brake thermal efficiency) clearly decreased under low engine loads, but increased by approximately 7.08% under high engine loads. In addition, concurrent decrease of NOx and PM as well as increase of HC and CO were observed. Furthermore, the particle size distribution shifted towards small-particle-diameter range, accompanied with more marked shift tendency with the increase of the premixed ratio of 2-butanol.