It is vital to identify and evaluate the optimal gasifier configuration that could be integrated with existing or new combined heat and power (CHP) plants to maximize the utilization of boiler operating capacity during off-peak hours with minimal effect on the boiler performance. This study aims to identify technically and economically most suitable gasification configuration and the reasonable operational limits of a CHP plant when integrated with different types of gasifiers. The selected gasifiers for the study are, (i) indirectly heated dual fluidized bed gasifier (DFBG), (ii) directly heated circulating fluidized bed gasifier (CFBG), and (iii) entrained flow gasifier (EFG). The gasifiers are selected on their ability to produce high-quality syngas from waste refused derived fuel (RDF). The syngas from the gasifiers is utilized to produce biomethane, whereas the heat and power from the CHP plant are consumed to run the gasification process. A detailed techno-economic analysis is performed using both flexible capacity and fixed capacity gasifiers and integrated with the CHP plant at full load. The results reveal that the integration leads to increase in operating time of the boiler for all gasifier configurations. The indirectly heated DFBG shows the largest biomethane production with less impact on the district heat and power production. Extra heat is available for biomethane production when the district heat and biomethane are prioritized, and the electric power is considered as a secondary product. Furthermore, the economic indicators reflect considerable dependency of integrated gasification performance on variable prices of waste biomass and biomethane.