This study was devoted to comprehensively investigating the exergetic performance of a gas-engine equipped anaerobic digestion plant producing electric power as well as biofertilizer from organic fraction of municipal solid waste (OFMSW). The main aim of the current survey was to reveal the reasons and sources of thermodynamic losses occurring in the plant based on real operational data. The required data for the analysis were collected from a local OFMSW anaerobic digestion plant located in Tehran, Iran. After writing energy and exergy balances for all components of the plant, their exergetic performance parameters were measured individually. An attempt was also undertaken to quantify the contributions of the products to the overall exergetic efficiency of the plant. The exergetic value of the net electric power was determined at 1596.0 kW, while the chemical exergetic content of the biofertilizer was found to be 8758.3 kW. The overall exergetic efficiency of the plant was determined at 72.8%. The contributions of the electric power and the biofertilizer to the overall exergetic efficiency of the plant were found to be 15.4% and 84.6%, respectively. Generally, the exergetic analysis presented herein could provide important guidelines and methodological blueprints for future investigations in order to develop thermodynamically-efficient and environmentally-benign waste-to-energy plants.