The design of an intensified reactive distillation (RD) configuration for the production of 2-methoxy-2-methylheptane (MMH) was proposed. Conventionally, a high yield of MMH can be achieved by a large-sized reactor or by recycling 2-methyl-1-heptene (MH). Both strategies are associated with high capital and operating costs. This study proposed an innovative RD configuration that allows the production of MMH with significantly lower energy costs and total annual costs (TACs). The results demonstrate that the proposed RD configuration can reduce energy demands and total annual costs by up to 18.2, and 10.8%, respectively, compared to those for a conventional reactor column sequence for the desired MMH yield. In addition, different heat integration sequences were investigated to utilize the sensible heat to save energy and the subsequent TAC. One heat integration sequence for the proposed configuration further realized savings in energy and TAC by up to 36.7 and 21.8%, respectively.