Desulfurization gypsum is a byproduct of limestone gypsum desulfurization. Preparation of desulfurization gypsum in CaCO3 and (NH4)(2)SO4 is a means of recycling. This paper presents integrated reaction and separation equipment and illustrates the desulfurization gypsum operation efficiency. Different additives and stirring programs were used to control crystal formation and explore nucleation growth. In addition, the separation mechanism and process characteristics of the integrated equipment have been assigned. Also, the flow trajectories and velocity contour were stimulated to study the separation characteristics, and the movement and distribution in the equipment were studied using a computational fluid dynamics approach. We found that a higher concentration of reactants leads to a higher separation efficiency. Moreover, the moisture content of solid products is low, and the solid liquid separation efficiency decreases when the liquid velocity increases. The best results are obtained with a chemical reaction conversion rate and separation efficiency of 83.14 and 81.83%, respectively.