The acoustic agglomeration has been admitted to be one of the effective ways for dust particle removal. In this study, a modified model for acoustic agglomeration of aerosol particles has been studied. The proposed model is featured by its full consideration of collision efficiency among aerosol particles with different sizes. Plus, the segmentation model for the acoustic agglomeration chamber has been established to investigate the process of particle agglomeration in the presence of sound field. An experimental system has been built to validate the model. Experimental results manifest that the model proposed in this study performs very well in depicting the process of acoustic agglomeration of aerosol particles. The model is then employed to investigate the influential factors that affect the collision efficiency between particles, including particle size, acoustic frequency and sound pressure level (SPL). Meanwhile, agglomeration effectiveness along the gas flow in the agglomeration chamber is investigated as well by the model. The work will contribute to the development of acoustic agglomeration for aerosol particle removal.