The solubility data of sodium L-ascorbate in water, methanol, ethanol, acetone, chloroform, ethyl acetate, isopropyl alcohol, isobutyl alcohol, n-hexane, water-methanol mixture and water-ethanol mixture have been determined in the temperatures range of 278.15-323.15 K by a static analytic method at atmospheric pressure. The experimental data were correlated with the modified Apelblat equation, CNIBS/R-K model, and Jouyban-Acree model. On the basis of the solubility data, a novel model-free design approach (semisuper-saturation control, SSSC) for combined cooling and antisolveht crystallization (CCAC) processes has been proposed and evaluated for sodium L-ascorbate in a methanol-water mixture. This approach can be easily implemented without complicated online monitors. Sodium L-ascorbate crystals with large and uniform morphology were obtained using the CCAC process, which was designed by the SSSC approach.