Vitamin E acetate (VEA) exhibits promising pharmacological action in the pharmaceutical and cosmetic industries. The solubility of VEA in supercritical carbon dioxide is measured to determine the cloud-point pressures in a high-pressure variable-volume view cell at various temperatures (i.e., 308.15, 313.15, 318.15, 323.15, and 328.15 K) and pressures (8-15 MPa). The experimental results indicate that the solubility of VEA can be improved by increasing pressure and reducing temperature in the experimental range. Furthermore, four density-based semiempirical models are employed to correlate and predict the experimental results, including Chrastil, Kumar and Johnston (K-J), Bartle, and Mendez-Santiago and Teja (MST) equations. The theoretical calculation results are consistent with the determinatal results. The relevant AARD values of Chrastil, K-J, Bartle, and MST are 6.62, 6.83, 6.80, and 7.19%, respectively.