In this work, the solubility data of syringic acid (SA) in eight mono solvents, including methanol, ethanol, 2-propanol, 1-butanol, 2-butanol, 1-hexanol, ethylene glycol, and ethyl acetate, and water + methanol mixtures were obtained experimentally in temperatures ranging from 283.15 to 323.15 K at 5 K intervals with a gravimetric method under a pressure of 0.1 MPa. It is found that the solubility of SA increases with increasing temperature in all selected pure and binary mixed solvents within the temperature range studied. The mole fraction solubility of SA is found to be highest in methanol and lowest in ethyl acetate. Additionally, three commonly used thermodynamic models, namely, the vant Hoff equation, the modified Apelblat, and lambda h models, were applied to correlate the experimental solubility data. It is found that the three empirical thermodynamic models can satisfactorily correlate the solubility of SA in the solvents under investigated temperatures. The excess enthalpy of the solutions was predicted. The experimental data and model parameters would be useful for optimizing the process of purification of syringic acid in industry.