In this work, we report a novel well-dispersed palladium nanoparticles (PdNPs)/nickel-phosphorus nanosheets (Ni-P NSs) synthesized by combination of red phosphorous phosphorization and simple electrodeposition technique. The obtained PdNPs/Ni-P nanosheets framework with large electrochemical active surface would not only exhibit much superior electrocatalytic activity (180.5 +/- 3.07 mA cm(-2)) toward glucose oxidation reaction, but also represent a wide linear range (2 mu M-4.65 mM) and high sensitive detection of glucose (242.5 +/- 3.28 mu A mM(-1) cm(-2)) as non-enzymatic glucose sensor. The three-dimensional (3D) PdNPs/Ni-P nanosheets have a promising prospect as a novel kind of highly active nanocatalyst and non-enzymatic electrochemical sensor. (c) 2017 Elsevier Inc. All rights reserved.