Nonaqueous redox flow batteries (NAqRFBs) are a promising, but nascent, concept for cost-effective grid-scale energy storage. While most studies report new active molecules and proof-of-concept prototypes, few discuss cell design. The direct translation of aqueous RFB design principles to nonaqueous systems is hampered by a lack of materials-specific knowledge, especially concerning the increased viscosities and decreased conductivities associated with nonaqueous electrolytes. To guide NAqRFB reactor design, recent techno-economic analyses have established an area specific resistance (ASR) target of <5 Omega cm(2). Here, we employ a state-of-the-art vanadium flow cell architecture, modified for compatibility with nonaqueous electrolytes, and a model ferrocene-based redox couple to investigate the feasibility of achieving this target ASR. We identify and minimize sources of resistive loss for various active species concentrations, electrolyte compositions, flow rates, separators, and electrode thicknesses via polarization and impedance spectroscopy, culminating in the demonstration of a cell ASR of ca. 1.7 Omega cm(2). Further, we validate performance scalability using dynamically similar cells with a ten-fold difference in active areas. This work demonstrates that, with appropriate cell engineering, low resistance nonaqueous reactors can be realized, providing promise for the cost-competitiveness of future NAqRFBs. (C) The Author(s) 2017. Published by ECS. All rights reserved.