Thermally Crosslinked Biocompatible Hydrophilic Polyvinylpyrrolidone Coatings on Polypropylene with Enhanced Mechanical and Adhesion Properties

Hayeong Jang; Hyungjoon Choi; Heejeong Jeong; Seolhee Baek; Singu Han; Dong June Chung; Hwa Sung Lee

Macromolecular Research, Vol.26, No.2, 151-156, February, 2018

DOI10.1007/s13233-018-6031-2 Export Citation

Thermally Crosslinked Biocompatible Hydrophilic Polyvinylpyrrolidone Coatings on Polypropylene with Enhanced Mechanical and Adhesion Properties

Hayeong Jang¹, Hyungjoon Choi^{2, 3}, Heejeong Jeong¹, Seolhee Baek¹, Singu Han¹, Dong June Chung^{3, †}, and Hwa Sung Lee^{1, †}

¹Department of Chemical and Biological Engineering, Hanbat National University, Daejeon 34158, Korea
²Noanix Corporation, 83 Deokamro35beongil, Cheongju, Chungbuk 28461, Korea
³Department of Polymer Science and Engineering, Sungkyunkwan University, Suwon, Gyeonggi 16419, Korea

E-mail:,

We developed a stable hydrophilic biocompatible hydrogel-forming coating for polypropylene (PP)-based disposal medical applications. Although PP has a variety of advantages, including good stability and inertness in medical applications, tissue damage and insertion resistance are observed upon insertion of PP-based devices into the human body due to the high hydrophobicity of the PP surface. These issues limit the utility of PP in medical applications. To address these problems, we sought to develop a stable hydrophilic and biocompatible hydrogel-forming layer using polyvinyl pyrrolidone (PVP) combined with a crosslinked polyethyleneglycolacrylate (PEGDA) matrix. Systematic studies of the blended hydrogel-forming PVP:PEGDA were conducted using a variety of blending ratios between the two polymers. The hydrophilicity and water-affinity of the hydrogel-forming layer improved significantly as the PEGDA-to-PVP blending ratio increased. Importantly, the tensile strain at the break point increased by a factor of more than 7, and the strength of adhesion to the PP surface for the 1:1 PVP:PEGDA (PVP(1):PEGDA(1)) blend ratio was 54 times that of the PVP film, determined using tensile strain?stress and peel tests. The water stability of the PVP(1):PEGDA(1) improved significantly. This approach is potentially useful as a biocompatible hydrophilic polymer coating in a variety of low-priced consumable PP commercial medical applications.

Keywords:polyvinylpyrrolidone;biocompatible hydrogel;hydrophilic coating;polypropylene;adhesion;polyethyleneglycolacrylate

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[Referenced By]

[1] Wheatley III GH, McNutt R, Diethrich EB, Ann. Thorac. Surg., 83, 272 (2007)

[2] Eisen LA, Narasimhan M, Berger JS, Mayo PH, Rosen MJ, Schneider RF, J. Intensive Care Med., 21, 40 (2006)

[3] Forauer AR, Theoharis C, J. Vasc. Interv. Radiol., 14, 1163 (2003)

[4] Usui M, Tanaka T, J. Cataract. Refract. Surg., 41, 1745 (2015)

[5] Kleinmann G, Marcovich AL, Apple DJ, Mamalis N, Br. J. Ophthalmol., 89, 1474 (2005)

[6] Barbeau GR, Catheter. Cardiovasc. Interv., 59, 442 (2003)

[7] Saito S, Tanaka S, Hiroe Y, Miyashita Y, Takahashi S, Satake S, Tanaka K, Catheter. Cardiovasc. Interv., 59, 305 (2003)

[8] Ikada Y, Tsuji H, Macromol. Rapid Commun., 21(3), 117 (2000)

[9] Jagur-Grodzinski J, Polym. Adv. Technol., 17, 395 (2006)

[10] Karode N, Fitzhenry L, Matthews S, Walsh P, Coffey A, Mater. Sci. Forum, 883, 75 (2017)

[11] Nair LS, Laurencin CT, Prog. Polym. Sci, 32, 762 (2007)

[12] Lipatova TE, Lipatov YS, Macromol. Symp., 152, 139 (2000)

[13] Hazer DB, Mut M, Dincer N, Saribas Z, Hazer B, Ozgen T, Childs Nerv. Syst., 28, 839 (2012)

[14] Ajili SH, Ebrahimi NG, Khorasani MT, J. Appl. Polym. Sci., 89(9), 2496 (2003)

[15] Saxena S, Ray AR, Kapil A, Djavid GP, Letourneur D, Gupta B, Pelle AM, Macromol. Biosci., 11, 373 (2011)

[16] Hoffman AS, Adv. Drug Deliv. Rev., 64, 18 (2012)

[17] Lin C, Metters AT, Adv. Drug Deliv. Rev., 58, 1379 (2006)

[18] Moon JJ, Hahn MS, Kim I, Nsiah BA, West JL, Tissue Eng. Part A, 15, 579 (2009)

[19] Gibas I, Janik H, Chem. Chem. Techonol., 4, 297 (2010)

[20] Dana SF, Nguyen D, Kochhar JS, Liu X, Kang L, Soft Matter, 9, 6270 (2013)

[21] Razzak MT, Darwis D, Zainuddin, Sukirno, Radiat. Phys. Chem., 62, 107 (2001)

[22] Mishra RK, Datt M, Banthia AK, PharmSciTech, 9, 395 (2008)

[23] Kaneda Y, Tsutsumi Y, Yoshioka Y, Kamada H, Yamamoto Y, Kodaira H, Tsunoda S, Okamoto T, Mukai Y, Shibata H, Nakagawa S, Mayumi T, Biomaterials, 25, 3259 (2004)

[24] Morent R, Geyter ND, Leys C, Cengembre L, Payen E, Surf. Interface Anal., 40, 597 (2008)

[25] Yagci Y, Sangermano M, Rizza G, Chem. Commun., 24, 2771 (2008)

[26] Braunecker WA, Matyjaszewski K, Prog. Polym. Sci, 32, 93 (2007)

[27] Li Y, Zhang R, Chen H, Zhang J, Suzuki R, Ohdaira T, Feldstein MM, Jean YC, Biomacromolecules, 4, 1858 (2003)

[28] Gershon AL, Gyger LS, Bruck HA, Gupta SK, Exp. Mech., 48, 789 (2008)

[29] Han HS, Kang HR, Kim SW, Kim HT, J. Power Sources, 112(2), 461 (2002)

[30] Qian T, Kim JH, Kumar S, Taylor PL, Phys. Rev. E, 61, 4007 (2000)

[31] Liu X, Won Y, Ma PX, J. Biomed. Mater. Res., 74A, 84 (2005)

[32] Bae M, Divan R, Suthar KJ, Mancini DC, Gemeinhart RA, J. Vac. Sci. Technol., 28, 24 (2010)

[33] Knauert ST, Douglas JF, Starr FW, J. Polym. Sci. B: Polym. Phys., 45(14), 1882 (2007)

[34] Roy N, Saha N, Kitano T, Saha P, Soft Matter, 8, 130 (2010)

[35] Wokovich AM, Prodduturi S, Doub WH, Hussain AS, Bruhse LF, Eur. J. Pharm. Biopharm., 64, 1 (2006)

[36] Bait N, Grassl B, Derail C, Benaboura A, Soft Matter, 7, 2025 (2011)

[37] Zhang J, Liu Z, Du H, Zeng Y, Xing L, Dong A, Pharm. Res., 26, 1398 (2009)

[38] Seo JC, Jang WB, Lee SK, Han HS, Polym. Degrad. Stabil., 93, 298 (2008)