The interesting and multifunctional properties of alpha-manganese dioxide (alpha-MnO2) are considered to be highly sensitive and selective to nitrogen dioxide (NO2) chemresistive gas sensors. The alpha-MnO2 mesoporous interlocked micro-cubes composed of several interconnected nanocrystals synthesized by a facile and low-cost hydrothermal method on soda-lime glass substrate are envisaged as selective and sensitive NO2 gas sensors. Phase-purity and surface area with pore-size distribution are initially screened. The three-dimensional alpha-MnO2 mesoporous-cube-based gas sensors tested for NO2 gas from room-temperature (27 degrees C) to 250 degrees C have demonstrated 33% response for 100 ppm NO2 levels at 150 degrees C. The response and recovery time values of the alpha-MnO2 sensor are found to be 26 s and recovery 91 s, respectively, with high selectivity, good sensitivity, and considerable chemical and environmental stabilities, confirming the gas sensor applications potentiality of alpha-MnO2 morphology which is a combination of interlocked mesoporous micro-cubes and well-connected nanocrystals. (C) 2018 Elsevier B.V. All rights reserved.