Background: Intestinal ischemia-reperfusion (I-R) injury is a serious abdominal condition leading to multiple organ failure with high mortality. However, no reliable treatment is available. A redox nano particle (RNP) was recently developed, and its efficacy for several intestinal inflammatory conditions has been reported. To this end, the aim of this study was to investigate the therapeutic effects of RNP on intestinal I-R injury in mice. Methods: Ischemia was induced in the small intestine of C57BL/6 mice by occluding the superior mesenteric artery for 45 min under anesthesia followed by reperfusion for 4 h. Mice were orally administered the vehicle or RNP 1 h before ischemia. Inflammatory markers such as histological findings, thiobarbituric acid (TBA)-reactive substances as an index of lipid peroxidation, myeloperoxidase (MPO) activity as an index of neutrophil infiltration, and expression of pro-inflammatory cytokine mRNA in the intestinal mucosa were assessed. Results: Induction of I-R caused a significant increase in inflammatory markers (histological scores, TBAreactive substances, MPO activity, and expression of keratinocyte chemoattractant, mRNA). These changes were significantly attenuated in RNP-treated mice as compared to vehicle-treated mice. Conclusion: Orally administered RNP attenuated intestinal I-R injury in mice in association with reductions in neutrophil infiltration and lipid peroxidation, suggesting the possibly potential of RNP as a therapeutic agent for intestinal I-R injury. (C) 2017 Elsevier Inc. All rights reserved.