A novel serial lantern-shaped draft tube (LDT) that generates vortices is proposed to increase radial velocity between dark and light regions for improving CO2 fixation with microalgae in a gas-lift circumflux column (GCC) photobioreactor. Clockwise vortices are generated in the downflow outerloop of the GCC photobioreactor with LDT. Radial velocity was improved from 1.50 to 4.35x10(-2) m/s, thereby decreased liquid cycle period between dark and light regions by 1.9 times. Mixing time decreased by 21%, and mass transfer coefficient increased by 26% with LDT. Liquid radial velocity in the downflow outerloop and mass transfer coefficient in the GCC photobioreactor both first increased and then decreased when single-lantern height was increased. Peak CO2 fixation rate increased from 0.62 to 0.87 g/L/d, microalgal biomass yield increased by 50%. Removal efficiencies of pollutants (chemical oxygen demand, ammonium, tilmicosin, and ethinylestradiol) in wastewater were 62-90% with microalgae growth in GCC photobioreactor with LDT.