A series of CoMo/TiO2-Al2O3 catalysts with different chelating agents were prepared by co-impregnation method. The influence of chelating agents on dispersions of active phase, textural properties, and hydrodesulfurization (HDS) activity for CoMo/TiO2-Al2O3 catalysts was studied. XRD characterization demonstrates that the addition of chelating agents can promote the dispersion degree of active components. TPR experiments exhibit an important effect of chelating agents on the catalysts. CoMo/TiO2-Al2O3 catalysts prepared with different chelating agents shows different HDS activity, and the addition of EDTA results in a remarkable improvement in both thiophene and DBT HDS conversions compared with others. [GRAPHICS] .