In pharmaceutical industry, micronization is used to achieve solubility enhancement through the increase in specific surface area, and finally improving the dissolution rate of the drug. Industrial application of micronization is mostly based on experience and trial and error method. This research deals with the micronization of dronedarone hydrochloride and the path for evaluation of characteristics of micronized drug. Micronization was performed in laboratory spiral jet mill and the samples were analyzed to determine particle size distribution, span of distribution, sphericity, shape, and specific surface area. Results were analyzed using analysis of variance and in terms of specific energy consumption. Paths for evaluation of particle size and span of distribution were proposed and good correlation between experimental and model results was achieved.