A graphene aerogel-zirconium-metal organic framework (GA-Zr-MOF) was synthesized and used as a membrane in a solid-phase extraction device to remove hydroquinone after immobilization of laccase. The adsorption rate of laccase onto this membrane reached 73.8mgg(-1), and it was mainly attributed to the adsorption effect of Zr-MOF. The membrane exhibited a satisfactory efficiency in removing hydroquinone (79%), which resulted from the combined effect of GA adsorption and catalysis by laccase. After five removal cycles, the removal rate remained at approximately 70%. The GA-Zr-MOF with immobilized laccase exhibited good operability and efficiency in the removal of hydroquinone.