Transient mixing and ignition mechanisms in a simplified pre-chamber/main-chamber system are investigated using direct numerical simulation (DNS) with detailed chemical kinetics. Full ignition and flame propagation processes in the premixed methane/air mixtures are simulated. Ignition, the progress and topology of flame evolution, and the mean burning velocity in the main chamber are analyzed in detail. Four important phases in the ignition and flame propagation processes are identified based on the flame structure development in the main chamber, the pressure and velocity evolution at typical points in both the pre-chamber and main chamber. Results show that the intermediate species OH, CH2O, and HO2 are critical for flame stabilization and propagation in the main chamber due to their high reactivity. This is sorted as the chemical effect that the pre-chamber jet acts on the main chamber. The high temperature jet also brings heat and unburned fuel into the main chamber, which are sorted as thermal and enrichment effect, respectively. The heat release rate is found to be approximately proportional to the product of CH2O and OH mass fractions, which could be regarded as a reliable and effective marker for the heat release rate of methane/air mixtures. It is found that the mean burning velocity in the main chamber can be elevated up to 30 times under the condition investigated. (C) 2017 The Combustion Institute. Published by Elsevier Inc. All rights reserved.