Non-noble metal electrocatalysts have emerged as promising next-generation electrocatalysts for oxygen reduction reaction (ORR). Despite considerable progress, non-noble metal electrocatalysts are plagued by relatively low efficiency and poor long-term stability. This study reports the design and synthesis of holey Co, N-codoped graphene aerogel with in-plane pores and multiple active sites (CoN-HGA) for efficient four-electron ORR in both alkaline and acid mediums. In particular, we use etched graphene oxide (GO) sheets with abundant in-plane pores to fabricate the aerogel and a porphyrin containing both Co and N elements as the doping precursor. The as-prepared CoN-HGA, thus, not only inherits abundant defective active sites from the etched GO sheets, but also has plenty of Co- and N-doped active sties. Furthermore, its holey structure creates abundant graphene sheet-sheet contacts as electron pathways, thereby greatly diminishing the resistance of the electrocatalyst. Meanwhile, the in-plane pores also serve as efficient mass transport channels, allowing full access to the internal active sites. Compared with commercial Pt/C (20 wt%), CoN-HGA exhibits slightly higher catalytic activity in alkaline medium and comparable activity in acidic medium with much improved stability and methanol tolerance. The synergetic effect from multiple active sites and unique structure provides a new route to design low-cost, high efficient ORR catalyst and beyond. (c) 2018 Elsevier Ltd. All rights reserved.