Knowing the pressure coefficient on building surfaces is important for the evaluation of wind loads and natural ventilation. The main objective of this paper is to present and to validate a computational modeling approach to accurately predict the mean wind pressure coefficient on the surfaces of flat-, gable- and hip-roofed rectangular buildings. This approach makes use of artificial neural network (ANN) to estimate the surface-average pressure coefficient for each wall and roof according to the building geometry and the wind angle. Three separate ANN models were developed, one for each roof type, and trained using an experimental database. Applied to a wide variety of buildings, the current ANN models were proved to be considerably more accurate than the commonly used parametric equations for the estimation of pressure coefficients. The proposed ANN-based methodology is as general and versatile as to be easily expanded to buildings with different shapes as well as to be coupled to building performance simulation and airflow network programs. (C) 2017 Elsevier B.V. All rights reserved.