In order to further improve the efficiency of the gas turbine, a novel combined supercritical CO2 regenerative cycle and organic Rankine cycle using zeotropic mixtures for waste heat recovery of gas turbine is proposed. The zeotropic mixtures used in the present study are cyclopentane/R365mfc. Exergoeconomic analysis is reported for the proposed system and parametric studies have been carried out to investigate the effect of system parameters on the exergy efficiency and the unit cost of electricity. The multi-objective optimization method based on genetic algorithm is chosen to obtain the optimum system parameters. The results show that the overall values of the exergoeconomic factor, the optimal exergy efficiency and the optimal unit cost of electricity of the proposed system are 31.88%, 62.23% and 3.95 cent/kW h, respectively. The obtained result reveals the superiority of the proposed combined regenerative S-CO2 cycle and ORC system compared to the combined basic S-CO2 cycle and ORC system, the combined recompression S-CO2 cycle and ORC system. Therefore, the proposed system is suitable for gas turbine waste heat recovery, and it has advantages of deep utilization of waste heat, high efficiency and low cost.