The objective of this work is to present a hybrid Organic Rankine Cycle (ORC) driven by solar energy and waste heat. Parabolic trough collectors coupled to a storage tank feed the heat recovery system which also utilizes waste heat of low-grade temperature (150 degrees C - 300 degrees C). Four different working fluids (toluene, cyclohexane, MDM and n-pentane) are examined in the regenerative ORC. The system is designed properly in order the maximum electricity production to be produced with the highest possible exploitation of the waste heat source. The examined model is investigated under steady-state conditions with a developed thermodynamic model in EES (Engineering Equation Solver). According to the final results, toluene leads to the highest electricity production, with cyclohexane, MDM and n-pentane to follow. The electricity production with toluene is found to be ranged from 479 kW to 845 kW and the system efficiency from 11.6% to 19.7%, with waste heat source temperature variation from 150 degrees C to 300 degrees C respectively. Moreover, it is found that higher waste heat source temperature leads to a higher fraction of the waste heat input in the ORC for all the working fluids.