In this work, solid-liquid equilibrium data of binary mixtures formed by n-hexadecane, a representative compound of fossil fuels, and ethyl esters present in ethylic biodiesel (ethyl oleate, ethyl laurate, ethyl palmitate, ethyl myristate and ethyl stearate) were determined through differential scanning calorimetry (DSC). Equilibrium data were thermodynamically modeled using the UNIFAC-Dortmund model for liquid-phase non-ideality, considering experimentally obtained transition properties (melting temperatures and enthalpies). The complex phase behavior of these systems may have unexpected impacts on the performance of blends of biodiesel and fossil fuels at low temperatures.