The present study focuses on the biorefinery approach of integrated production of bioethanol and biodiesel from microalgae feedstock. Various pretreatment methods were used to determine the maximum recovery of sugars from Scenedesmus sp. The total sugar yield of 93% was obtained when the biomass was pretreated by acid hydrolysis. The hydrolysate produced 86% of ethanol (theoretical yield) after the fermentation using Saccharomyces cerevisiae. Enzyme catalyzed direct transesterification of the biomass was performed using dimethyl carbonate as a solvent and the maximum yield of 92% methyl ester, 1.86% glycerol carbonate and 4.93% glycerol dicarbonate was achieved. The integrated process of bioethanol and biodiesel production was optimally achieved when direct transesterification was done first followed by ethanol fermentation yielding 92 and 93% of methyl ester and ethanol, respectively.