Thermodynamic equilibrium analysis has been adopted for oxidative steam reforming of butanol-ethanol mixture (B-E) as renewable source obtained from Acetone:Butanol:Ethanol (ABE) fermentation to produce H-2 by using Gibbs free energy minimization method. The effects of pressure (1-10 atm), temperature (573-1473 K), steam/fuel molar feed ratio f(O1) = 9 and 12), O-2/fuel molar feed ratio (f(O2)= 0-3), and B-E mixture compositions (50-90% B) on equilibrium compositions of H-2, CO, CO2, CH4, and carbon are performed. The maximum H-2 yield (65.456% for f(O2) = 0 and 58% for f(O2) = 0.75) has been achieved at f(O1) = 9, 90% B mixture, 1 atm, and 973 K. The yields of CO, CO2, and CH4 with respect to maximum H-2 are 53.390%, 44.384%, and 2.225% for f(O2) = 0, and 45.677%, 53.269%, and 1.053% for f(O2) = 0.75, respectively. Energy required per mol of H-2, thermal and exergy efficiencies for the process are also evaluated to utilize the potential of B-E mixture for H-2 production. (C) 2018 Hydrogen Energy Publications LLC. Published by Elsevier Ltd. All rights reserved.