Isobaric vapor liquid equilibrium (VLE) data for binary systems of n hexane + 1,2-dimethoxyethane and methylcyclopentane + 1,2-dimethoxyethane were measured at 101.3 kPa with an Ellis vapor-liquid equilibrium still, and the thermodynamic consistency of the experimental data Was checked and passed by the Herington method and Wisniak test. The VLE values were correlated with the nonrandom two-liquid, universal quasichemical and Wilson activity coefficient models, and the corresponding binary interaction parameters of the three models were obtained. The results correlated with three models have good agreement with the experimental data, indicating that the three models were all fitted well.