The solubilities of amorphous form, alpha-form, and beta-form of taltirelin (TTL) in water, ethanol, 1-propanol, and 2-propanol were measured over temperatures ranging from 273.2 to 323.2 K under atmospheric pressure. The experimental data were modelled using the modified Apelblat model. The dissolution enthalpy and entropy of dissolution of TTL polymorphic form in pure solvents were also determined using the van't Hoff equation. The results reveal that the dissolution of TTL in each solvent is an entropy-driven process.