Journal of the American Chemical Society, Vol.140, No.14, 4787-4791, 2018
Efficient Multicomponent Active Template Synthesis of Catenanes
We describe a simple and high yielding active template synthesis of [2]catenanes. In addition to mechanical bond formation using a single premacrocycle bearing an azide and alkyne moiety, our method is also suitable for the co-macrocydization of readily available bis-alkyne and bis-azide comonomers and even short alkyne/azide components which oligomerize prior to mechanical bond formation.