It is a photochemist's dream, to be able to photoinduce a reaction of a specific Molecular species in an ensemble of similar but not identical ones. The problem Is that similar molecules often exhibit nearly identical UV-Vis absorption spectra, making them difficult or impossible to distinguish or to select Spectroscopically. The ultrafast VIPER (VIbrationally, Promoted Electronic Resonance) pulse sequence allows to pick a single species for electronic excitation based on its infrared spectrum. The latter usually shows more features, allowing the discrimination between species than the UV-Vis spectrum. Here, we show that it is possible to induce and monitor species-selective photochemistry even for molecules with virtually identical UV-Vis spectra, which-is the case for isotopomers. Next orthogonal photo-uncaging and species-selective spectroscopy an to isotope-selective photochemistry in solution, applications and photochemistry in mixtures are within reach.