The microstructure of high-temperature metals such as Ti, Ni, and Cr can be modified using ceramic nanoparticles to form metal matrix nanocomposites (MMNCs). Such materials are generally prepared via powder metallurgy routes. In this study, 25 wt% SiCnp and Al2O3np were separately ball milled as a reinforcement of Ti, Cr, and Ni matrices to investigate their effects on the phase formation and morphology of the MMNCs. The x-ray diffraction (XRD), scanning electron microscopy (SEM), and field emission scanning electron microscopy (FESEM) results indicated that the alumina-metal system could not be thermodynamically stable in a high-energy ball mill, while the SiC reinforcement could be retained and milled with the metals even after 24 h. It was further observed that the distribution of nanoparticles was not affected by the type of metal, ceramic, and milling time. Finally, it was determined that the nanoparticles significantly reduced the average particle size of composite powders.