Hybrid nanofluids are a novel class of colloidal fluids which have drawn significant attention due to potential tailoring of their thermo-physical properties for heat transfer enhancement by a combination of more than one nano-additive to meet specific requirements of an application. In the present work, ceramic copper oxide/carbon (SiO2-CuO/C) nanoparticles in 80:20 (wt%) composition were prepared by ultrasonic-assisted wet mixing technique. The hybrid nanofluid was formulated by dispersing the nanoparticles into a base fluid mixture of 60:40 (% by mass) glycerol and ethylene glycol (G/EG) using the two-steps method. The influence of nano-particles on the augmentation of specific heat, thermal conductivity and viscosity was examined in the volume concentration range of 0.5-2.0% in the temperature range of 303.15-353.15 K. The results demonstrate that the synthesized SiO2-CuO/C hybrid nanoparticles enhanced the thermo-physical properties of the base fluid mixture which is higher than using SiO2 alone. In the case of SiO2-G/EG nanofluid, the specific heat capacity decremented by a maximum value of 5.7% whereas the thermal conductivity and viscosity incremented by 6.9% and 1.33-times as compared with G/EG at maximum volume concentration of 2.0% at a temperature of 353.15 K. Comparatively, a reinforcement of 80% SiO2 with 20% CuO/C in G/EG mixture led to thermal conductivity and viscosity enhancement by 26.9% and 1.15-times, respectively with a significant reduction of specific heat by 21.1%. New empirical correlations were proposed based on the experimental data for evaluation of thermophysical properties.