코아세르베이션된 약물 함유 콘택트렌즈에서의 약물의 확산 연구

김근희; 이종진; 김근희; Guenhei Kim; Jongjin Lee; Hyeran Noh

Polymer(Korea), Vol.42, No.3, 427-433, May, 2018

DOI10.7317/pk.2018.42.3.427 Export Citation

코아세르베이션된 약물 함유 콘택트렌즈에서의 약물의 확산 연구

Study of Drug Release from Hydrogel Contact Lens Containing Coacervated Drugs

김근희¹, 이종진², 김근희^{1, 2, †}

¹서울과학기술대학교 의공학 바이오소재(융합협동 프로그램)
²서울과학기술대학교 안경광학과

Guenhei Kim¹, Jongjin Lee², and Hyeran Noh^{1, 2, †}

¹Convergence Institute of Biomedical Eng. & Bio., Seoul National University of Science and Technology, 138 Gongneung gil, Nowon-gu,,Seoul 01811, Korea
²Department of Optometry, Seoul National University of Science and Technology, 138 Gongneung gil, Nowon-gu, Seoul 01811, Korea

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초록

본 연구에서는 난용성인 리도케인과 친유성인 비타민 E를 상분리한 후 콘택트렌즈와 중합하였다. 제조된 약물 렌즈의 물리적 특성과 약물 방출 현상을 연구하였다. 하이드로젤 콘택트렌즈는 HEMA, EGDMA 및 AIBN를 일정 비율로 혼합하였고, 약물은 안구 국소 마취수술에 사용되는 리도케인과 백내장 예방 효과가 있는 비타민 E를 각각 사용하였다. 코아세르베이션된 리도케인과 비타민 E 제형과 HEMA 고분자를 교반하여 열 중합으로 렌즈를 제조하였다. 약물 콘택트렌즈의 광 투과율(UV-B, UV-A, Visible) 및 수분 함량을 측정하였고, 표면 특성과 입자 분석은 광학 현미경 및 입도 분석기를 사용하였다. 약물 방출량은 UV-spectrophotometer로 측정하여 분석하였다. 그 결과, 약물 비함유 콘택트렌즈(p-HEMA 100 wt%)와 비교하여 코아세르베이션 약물 렌즈의 광투과율은 낮게 나타났다. 반면, 함수율은 각각 4.10%, 3.62% 약간 증가하였고, 약물의 방출기간은 최소 3일에서 최대 19일까지 연장되었다. 계면 활성제를 이용한 코아세르베이션된 약물 입자의 제조로 콘택트렌즈에서 약물의 지속적인 방출이 가능하였다. 코아세르베이션된 약물을 함유하는 콘택트렌즈는 장기적인 치료가 필요한 안구 질환에 적합한 약물 전달 렌즈로의 응용이 가능하다.

Poorly soluble lidocaine and lipophilic vitamin E were phase-separated and polymerized with monomer to form contact lenses. The physical properties and drug release of the manufactured lenses were studied. The used drugs were lidocaine, for local anesthesia, and vitamin E, anti-cataract effect. The HEMA lenses were thermally polymerized with coacervated lidocaine and vitamin E. We measured the light transmittance and water content of drug-containing contact lenses. Optical microscopes and particle size analyzers were used for surface and particle analysis. As a result, the light transmittance of the coacervation drug lens was lower than that of the no-drug lens. However, water content of coacervated drug lens was slightly increased and the drug releasing period was prolonged. The preparation of coacervated drugs enables sustained release of the hardly soluble drugs in the lens. The contact lenses containing coacervated drugs can be used as drug delivery lenses for the prolonged treatment of eye diseases.

Keywords:drug releasing contact lens;coacervation contact lens;drug diffusion;lidocaine;vitamin E

[References]

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Nikouei BM, Vahabzadeh SA, Mohajeri SA, Curr. Drug Deliv., 10, 279 (2013)
Yanez F, Martikainen L, Braga ME, Alvarez-lorenzo C, Concheiro A, Duarte CM, Gil MH, De Sousa HC, Acta Biomater., 7, 1019 (2011)
Carrier RL, Miller LA, Ahmed I, J. Control. Release, 123, 78 (2007)
Fawaz F, Bonini F, Guyot M, Bildet J, Maury M, Lagueny AM, Int. J. Pharm., 132, 271 (1996)
De Jaeghere W, De Geest BG, Van Bocxlaer J, Remon JP, Vervaet C, da Fonseca AA, Eur. J. Pharm. Biopharm., 85, 930 (2013)
Das S, Banerjee R, Bellare J, Trends Biomater. Artif. Organs, 18, 203 (2005)
Dong W, Bodmeier R, Int. J. Pharm., 326, 128 (2006)
Hao J, Wang F, Wang X, Zhang D, Bi Y, Gao Y, Xuemei Z, Zhang Q, Eur. J. Pharm. Sci., 47, 497 (2012)
Sebak S, Mirzaei M, Malhotra M, Kulamarva A, Prakash S, Int. J. Nanomedicine, 5, 525 (2010)
Jyothi NVN, Prasanna PM, Sakarkar SN, Prabha KS, Ramaiah PS, Srawan GY, J. Microencapsul., 27(3), 187 (2010)
Gorner T, Gref R, Michenot D, Sommer F, Tran MN, Dellacherie E, J. Control. Release, 57, 259 (1999)
Ritger PL, Peppas N, J. Control. Release, 5, 23 (1987)
Korsmeyer RW, Peppas NA, J. Membr. Sci., 9, 211 (1981)
Tomar N, Tomar M, Gulati N, Nagaich U, Inter. J. Health Allied Sci., 1, 224 (2012)
Kapoor Y, Thomas JC, Tan G, John VT, Chauhan A, Biomaterials, 30, 867 (2009)
Braga ME, Costa VP, Pereira MJ, Fiadeiro PT, Gomes APA, Duarte CM, de Sousa HC, Int. J. Pharm., 420, 231 (2011)
Veis A, Adv. Colloid Interface Sci., 167, 2 (2011)
Gorner T, Gref R, Michenot D, Sommer F, Tran MN, Dellacherie E, J. Control. Release, 57, 259 (1999)
Saberi AH, Fang Y, McClements DJ, J. Colloid Interface Sci., 391, 95 (2013)

[Referenced By]

[1] Novack GD, Clin. Pharmacol. Therap., 85, 539 (2009)

[2] Carvalho IM, Marques CS, Oliveira RS, Coelho PB, Costa PC, Ferreira DC, J. Control. Release, 202, 76 (2015)

[3] Lang JC, Adv. Drug Deliv. Rev., 16, 39 (1995)

[4] Wichterle O, Lim D, Nature, 185, 117 (1960)

[5] Sedlavek J, Cesk Oftalmol, 21, 509 (1965)

[6] Chauhan A, Delhi J. Ophthalmol., 26, 131 (2015)

[7] Mohammadi S, Jones L, Gorbet M, Plos one, 9, 1 (2014)

[8] Ciolino JB, Hudson SP, Mobbs AN, Hoare TR, Iwata NG, Fink GR, Kohane DS, Invest. Ophth. Vis. Sci., 52, 6286 (2011)

[9] Nikouei BM, Vahabzadeh SA, Mohajeri SA, Curr. Drug Deliv., 10, 279 (2013)

[10] Yanez F, Martikainen L, Braga ME, Alvarez-lorenzo C, Concheiro A, Duarte CM, Gil MH, De Sousa HC, Acta Biomater., 7, 1019 (2011)

[11] Carrier RL, Miller LA, Ahmed I, J. Control. Release, 123, 78 (2007)

[12] Fawaz F, Bonini F, Guyot M, Bildet J, Maury M, Lagueny AM, Int. J. Pharm., 132, 271 (1996)

[13] De Jaeghere W, De Geest BG, Van Bocxlaer J, Remon JP, Vervaet C, da Fonseca AA, Eur. J. Pharm. Biopharm., 85, 930 (2013)

[14] Das S, Banerjee R, Bellare J, Trends Biomater. Artif. Organs, 18, 203 (2005)

[15] Dong W, Bodmeier R, Int. J. Pharm., 326, 128 (2006)

[16] Hao J, Wang F, Wang X, Zhang D, Bi Y, Gao Y, Xuemei Z, Zhang Q, Eur. J. Pharm. Sci., 47, 497 (2012)

[17] Sebak S, Mirzaei M, Malhotra M, Kulamarva A, Prakash S, Int. J. Nanomedicine, 5, 525 (2010)

[18] Jyothi NVN, Prasanna PM, Sakarkar SN, Prabha KS, Ramaiah PS, Srawan GY, J. Microencapsul., 27(3), 187 (2010)

[19] Gorner T, Gref R, Michenot D, Sommer F, Tran MN, Dellacherie E, J. Control. Release, 57, 259 (1999)

[20] Ritger PL, Peppas N, J. Control. Release, 5, 23 (1987)

[21] Korsmeyer RW, Peppas NA, J. Membr. Sci., 9, 211 (1981)

[22] Tomar N, Tomar M, Gulati N, Nagaich U, Inter. J. Health Allied Sci., 1, 224 (2012)

[23] Kapoor Y, Thomas JC, Tan G, John VT, Chauhan A, Biomaterials, 30, 867 (2009)

[24] Braga ME, Costa VP, Pereira MJ, Fiadeiro PT, Gomes APA, Duarte CM, de Sousa HC, Int. J. Pharm., 420, 231 (2011)

[25] Veis A, Adv. Colloid Interface Sci., 167, 2 (2011)

[26] Gorner T, Gref R, Michenot D, Sommer F, Tran MN, Dellacherie E, J. Control. Release, 57, 259 (1999)

[27] Saberi AH, Fang Y, McClements DJ, J. Colloid Interface Sci., 391, 95 (2013)