Near-infrared fluorescent sorbitol probe for tumor diagnosis in vivo

Sungsu Lee; Wonbong Lim; Danbi Jo; Jin Seok Jung; Subin Kim; Gayoung Jo; Jung-Joon Min; Eun Young Choi; Hoon Hyun

Journal of Industrial and Engineering Chemistry, Vol.64, 80-84, August, 2018

DOI10.1016/j.jiec.2018.02.004 Export Citation

Near-infrared fluorescent sorbitol probe for tumor diagnosis in vivo

Sungsu Lee, Wonbong Lim¹, Danbi Jo², Jin Seok Jung², Subin Kim², Gayoung Jo², Jung-Joon Min³, Eun Young Choi^{4, †}, and Hoon Hyun^{2, †}

Department of Otolaryngology—Head and Neck Surgery, Chonnam National University Medical School, Gwangju 61469, South Korea
¹Department of Premedical Program, School of Medicine, Chosun University, Gwangju 61452, South Korea
²Department of Biomedical Sciences, Chonnam National University Medical School, Gwangju 61469, South Korea
³Department of Nuclear Medicine, Chonnam National University Medical School, Gwangju 61469, South Korea
⁴Department of Biomedical Sciences, University of Ulsan College of Medicine, Seoul 05505, South Korea

E-mail:,

This study evaluated the near-infrared (NIR) fluorescent probe Sorbitol-ZW800-1 as tracer for targeted tumor imaging of multiple cancer types. Preliminarily, Sorbitol-ZW800-1 conjugate was validated in vivo on breast (MCF-7) cancer cell lines. Subsequently, the tracer was tested in xenograft mouse models with malignant breast (MDA-MB-231), lung (NCI-H460), and colorectal (HT-29) tumors, respectively. Importantly, the Sorbitol-ZW800-1 conjugate showed highly selective tumor uptake in various tumor mice models. Moreover, biodistribution for 24 h exhibited the significant fluorescence signals in tumors and kidneys. Therefore, sorbitol is a promising candidate as a potential cancer targeting agent for the accurate detection of cancer cells.

Keywords:Sorbitol;ZW800-1;Tumor targeting;Near-infrared fluorescence;Optical imaging

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[1] Ma YY, Jin KT, Wang SB, Wang HJ, Tong XM, Huang DS, Mou XZ, Contrast Media Mol. Imaging, 2017, 102627 (2017)

[2] Gurfinkel M, Ke S, Wen X, Li C, Sevick-Muraca EM, Dis. Mark., 19, 107 (2003)

[3] Jo D, Hyun H, Chonnam Med. J., 53, 95 (2017)

[4] Hyun H, Park MH, Owens EA, Wada H, Henary M, Handgraaf HJ, Vahrmeijer AL, Frangioni JV, Choi HS, Nat. Med., 21, 192 (2015)

[5] Lim W, Sohn H, Ko Y, Park M, Kim B, Jo D, Jung JS, Yang DH, Kim J, Kim OJ, Kim D, Moon YL, Min JJ, Hyun H, Oncotarget, 8, 65770 (2017)

[6] Hyun H, Wada H, Bao K, Gravier J, Yadav Y, Laramie M, Henary M, Frangioni JV, Choi HS, Angew. Chem.-Int. Edit., 53, 10668 (2014)

[7] Hyun H, Owens EA, Wada H, Levitz A, Park G, Park MH, Frangioni JV, Henary M, Choi HS, Angew. Chem.-Int. Edit., 54, 8648 (2015)

[8] Hyun H, Henary M, Gao T, Narayana L, Owens EA, Lee JH, Park G, Wada H, Ashitate Y, Frangioni JV, Choi HS, Mol. Imaging Biol., 18, 52 (2016)

[9] Choi HS, Gibbs SL, Lee JH, Kim SH, Ashitate Y, Liu F, Hyun H, Park G, Xie Y, Bae S, Henary M, Frangioni JV, Nat. Biotechnol., 31, 148 (2013)

[10] Choi HS, Nasr K, Alyabyev S, Feith D, Lee JH, Kim SH, Ashitate Y, Hyun H, Patonay G, Strekowski L, Henary M, Frangioni JV, Angew. Chem.-Int. Edit., 50, 6258 (2011)

[11] Hyun H, Bordo MW, Nasr K, Feith D, Lee JH, Kim SH, Ashitate Y, Moffitt LA, Rosenberg M, Henary M, Choi HS, Frangioni JV, Contrast Media Mol. Imaging, 7, 516 (2012)

[12] Lee S, Lim W, Ryu HW, Jo D, Min JJ, Kim HS, Hyun H, Int. J. Med. Sci., 14, 1430 (2017)

[13] Teo G, Suzuki Y, Uratsu SL, Lampinen B, Ormonde N, Hu WK, DeJong TM, Dandekar AM, Proc. Natl. Acad. Sci. U. S. A., 103, 18842 (2006)

[14] Calvaresi EC, Hergenrother PJ, Chem. Sci., 4, 2319 (2013)

[15] Bruns OT, Bischof TS, Harris DK, Franke D, Shi Y, Riedemann L, Bartelt A, et al., Nat. Biomed. Eng., 1, 0056 (2017)

[16] Grimm D, Bauer J, Pietsch J, Infanger M, Eucker J, Eilles C, Schoenberger J, Curr. Med. Chem., 18, 176 (2011)

[17] Verma S, Miles D, Gianni L, Krop IE, Welslau M, Baselga J, Pegram M, et al., N. Engl. J. Med., 367, 1783 (2012)

[18] Visentin M, Zhao R, Goldman ID, Hematol. Oncol. Clin. North Am., 26, 629 (2012)

[19] Parker N, Turk MJ, Westrick E, Lewis JD, Low PS, Leamon CP, Anal. Biochem., 338, 284 (2005)

[20] Ohba S, Fujii H, Ito S, Fujimaki M, Matsumoto F, Furukawa M, Yokoyama J, Kusunoki T, Ikeda K, Hino O, J. Oral Pathol. Med., 39, 74 (2010)

[21] Gambhir SS, Nat. Rev. Cancer, 2, 683 (2002)

[22] Behl T, Kaur I, Kotwani A, Surv. Ophthalmol., 61, 187 (2016)

[23] Koyama AH, Arakawa T, Adachi A, Microbes Infect., 2, 599 (2000)

[24] Lu X, Li C, Wang YK, Jiang K, Gai XD, Oncol. Lett., 7, 1992 (2014)

[25] Lee DW, Jo JH, Jo DB, Kim JH, Min JJ, Yang DH, Hyun H, J. Ind. Eng. Chem., 57, 37 (2018)